Background Clinical papers so flawed that they are eventually retracted may put patients at risk. Patient risk could arise in a retracted primary study or in any secondary study that draws ideas or inspiration from a primary study. Methods To determine how many patients were put at risk, we evaluated 788 retracted English-language papers published from 2000 to 2010, describing new research with humans or freshly derived human material. These primary papers—together with all secondary studies citing them—were evaluated using ISI (...) Web of Knowledge. Excluded from study were 468 basic science papers not studying fresh human material; 88 reviews presenting older data; 22 case reports; 7 papers retracted for journal error and 23 papers unavailable on Web of Knowledge. Overall, 180 retracted primary papers (22.8%) met the inclusion criteria. Subjects enrolled and patients treated in 180 primary studies and 851 secondary studies were combined. Results Retracted papers were cited over 5000 times, with 93% of citations being research related, suggesting that ideas promulgated in retracted papers can influence subsequent research. Over 28 000 subjects were enrolled—and 9189 patients were treated—in 180 retracted primary studies. Over 400 000 subjects were enrolled—and 70 501 patients were treated—in 851 secondary studies which cited a retracted paper. Papers retracted for fraud (n=70) treated more patients per study (p<0.01) than papers retracted for error (n=110). Conclusions Many patients are put at risk by retracted studies. These are conservative estimates, as only patients enrolled in published clinical studies were tallied. (shrink)

This paper examines patterns of metaphor in usage. Four samples of text excerpts of on average 47,000 words each were taken from the British National Corpus and annotated for metaphor. The linguistic metaphor data were collected by five analysts on the basis of a highly explicit identification procedure that is a variant of the approach developed by the Pragglejaz Group (Metaphor and Symbol 22: 1–39, 2007). Part of this paper is a report of the protocol and the reliability of the (...) procedure. Data analysis shows that, on average, one in every seven and a half lexical units in the corpus is related to metaphor defined as a potential cross-domain mapping in conceptual structure. It also appears that the bulk of the expression of metaphor in discourse consists of non-signalled metaphorically used words, not similes. The distribution of metaphor-related words, finally, turns out to be quite variable between the four registers examined in this study: academic texts have 18.5%, news 16.4%, fiction 11.7%, and conversation 7.7%. The systematic comparative investigation of these registers raises new questions about the relation between cognitive linguistic and other approaches to metaphor. (shrink)

Media attention to retracted research suggests that a substantial number of papers are corrupted by misinformation. In reality, every paper contains misinformation; at issue is whether the balance of correct versus incorrect information is acceptable. This paper postulates that analysis of retracted research papers can provide insight into medical misinformation, although retracted papers are not a random sample of incorrect papers. Error is the most common reason for retraction and error may be the principal cause of misinformation as well. Still, (...) one-quarter of retracted papers are fraudulent, and misinformation may also arise through fraud. This paper hypothesises that error and fraud are the main sources of misinformation and that error is more common than fraud. Retraction removes misinformation from the literature; bias is non-retracted misinformation. Bias arises when scientific impropriety results in false research findings. Impropriety can involve experimental design, data collection, data analysis, or data presentation. Yet impropriety also arises through earnest error or statistical naiveté; not all bias is fraud. Several measures are proposed to minimise misinformation in the medical literature, including: greater detail in the clinical trial registry, with rigorous definition of inclusion and exclusion criteria and primary endpoints; clear statistical criteria for every aspect of clinical trials, especially sample size; responsibility for data integrity that accrues to all named authors; increased transparency as to how the costs of research were paid; and greater clarity as to the reasons for retraction. Misinformation can arise without malicious intent; authors of incorrect papers are owed a presumption of incompetence, not malice. (shrink)

Summary Influenced by the account of K. Popper and, moreover, of C. G. Hempel and P. Oppenheim, it is generally assumed, that a prediction can be logically deduced from hypotheses, i. e. lawlike propositions, and initial conditions. It is not clear, in which respect a prediction can correctly be supposed to be a proposition which is either true or false. From a logical point of view, serious difficulties arise in assuming that the deductive-nomological model consists of a valid argument. Further (...) objections to this account are developed with regard to lawlike propositions. Since a lawlike proposition is — by definition — not true or definitely true, but only supposed to be true, it cannot function as a true premise among other true premises for the purpose of deduction. Special difficulties arise with regard to predictions: A predictive argument does not give any reason for the truth of the predictionK, but only — if at all — for the prediction of the truth ofK. In the latter case, the conclusion K clearly does not consist of a proposition (which could be either true or false) but rather of a predicting proposition. (shrink)

It seems that actions are perceived from two different perspectives: on the one hand by the agent of the action and on the other hand by the observer. The latter perspective appears to be more reliable because of inter-subjective observations. Hence, determinists argue that actions can be causally explained by events, whereas the indeterminists claim that actions are acausal events. If e.g. Mary opens the door, we observe her behaviour but not her action; for it is not clear to us (...) from our observations whether she intends to open the door, whether she opens the door unconsciously or whether she opens the door only accidentally when sleepwalking. Since actions do not consist in events, their observations involve behaviouristic fallacy. Consequently, deterministic as well as indeterministic arguments prove to be untenable. Since only the first perspective, i.e. that of the agent, remains, it is necessary to refer to the reports about their actions and to our observations of their behaviour when explicating the concept of action. This enables us to clarify the question of how far human beings are free to do, or not to do, what they want. (shrink)

Developers and designers make all sorts of moral decisions throughout an innovation project. In this article, we describe how teams of developers and designers engaged with ethics in the early phases of innovation based on case studies in the SUBCOP project. For that purpose, Value Sensitive Design will be used as a reference. Specifically, we focus on the following two research questions: How can researchers/developers learn about users’ perspectives and values during the innovation process? and How can researchers/developers take into (...) account these values, and related design criteria, in their decision-making during the innovation process? Based on a case study of several innovation processes in this project, we conclude the researchers/developers involved are able to do something similar to VSD, supported by relatively simple exercises in the project, e.g., meetings with potential end-users and discussions with members of the Ethical Advisory Board of the project. Furthermore, we also found—possibly somewhat counterintuitively—that a commercial, with its focus on understanding and satisfying customers’ needs, can promote VSD. (shrink)

Roderick Chisholm changed his mind about ordinary objects. Circa 1973-1976, his analysis of them required the positing of two kinds of entities—part-changing ens successiva and non-part-changing, non-scatterable primary objects. This view has been well noted and frequently discussed (e.g., recently in Gallois 1998 and Sider 2001). Less often treated is his later view of ordinary objects (1986-1989), where the two kinds of posited entities change, from ens successiva to modes, and, while retaining primary objects, he now allows them to survive (...) spatial scatter. Also (to my knowledge) not discussed is why he changed his mind. This paper is mostly intended to fill in these gaps, but I also give some additional reasons to prefer Chisholm's later view. Also, I discuss how mereological essentialism can be further defended by how it informs a theory of property-inherence which steers between the excesses of the bare particularists and bundle theorists. (shrink)

From five plausible premises about ordinary objects it follows that ordinary objects are either functions, fictions or processes. Assuming that the function and fiction accounts of ordinary objects are not plausible, in this paper I develop and defend a (non-Whiteheadian) process account of ordinary objects. I first offer an extended deduction that argues for mereological essentialism for masses or quantities, and then offer an inductive argument in favor of interpreting ordinary objects as processes. The ontology has two main types of (...) entities, masses of matter and processes. A cat, for instance, is shown to be a ‘catting’ process that migrates through distinct portions of matter, much like how a wave passes through distinct portions of water. I also show how the account solves the paradox of coincidence, the Ship of Theseus, fusion cases (e.g. Tib/Tibbles), and answers the Special Composition Question. (shrink)

A diagnosis of dementia often comes with difficulties in understanding a conversational context and expressing how one feels. So far, research on how to facilitate advance care planning for people with dementia focused on defining relevant themes and topics for conversations, or on how to formalize decisions made by surrogate decision makers, e.g., family members. The aim of this review is to provide a better scope of the existing research on practical communication aspects related to dementia in ACP conversations. In (...) November 2020, seven databases were searched to select papers for inclusion. This search was updated in December 2021. The search strategy consisted of three tiers, intersected by using the Boolean term “AND,” and resulted in 787 studies. Two researchers followed explicit criteria for two sequential levels of screening, based on titles and abstracts and full papers. A total of 22 studies were included for data analysis. Seven topics emerged clustered around two themes. This scoping review provides practical suggestions for healthcare professionals to improve ACP communication and uncovered gaps in research on communication aspects related to dementia in ACP conversations, such as non-verbal behavior, timing and implementation, and personal preferences. (shrink)

This book explores the relationship between people living relatively simple lives and the cultural complexity of their live worlds by rethinking culture in terms of complexity theory.

Steen Brock paints a cross-disciplinary picture of the philosophical and scientific background for the rise of the quantum theory. He accounts for the unity of Kantian metaphysics of Nature, the Helmholtzian principles, and the Hamiltonian methods of modern pre-quantum physics. Brock shows how Planck's vision of a generalization of classical physics implies that the original quantum mechanics of Heisenberg can be regarded as a successful attempt to maintain this modern unity of physics.However, for Niels Bohr, the unity of science (...) and metaphysics did not end in the world of physics. The development of quantum physics had general implications both for other sciences and for various philosophical issues. Brock discusses these matters with respect to recent topics within the philosophy of science and major interpretations of Bohr's ideas. The author invites the reader to follow a long andwinding route of thought which, in the end, culminates in Bohr's ideas of complementarity, culture and Spirit. (shrink)

This inclusive cross-cultural study rethinks the nexus between engineering education and context. In so doing the book offers a reflection on contextual boundaries with an overall boundary crossing ambition and juxtaposes important cases of critical participation within engineering education with sophisticated scholarly reflection on both opportunities and discontents. Whether, and in what way engineering education is or ought to be contextualized or de-contextualized is an object of heated debate among engineering educators. The uniqueness of this study is that this debate (...) is given comprehensive coverage - presenting both instrumentally inclined as well as radical positions on transforming engineering education. In contextualizing engineering education, this book offers diverse commentary from a range of disciplinary, meta- and interdisciplinary perspectives on how cultural, professional, institutional, and educational systems contexts shape histories, structural dynamics, ideologies and challenges as well as new pathways in engineering education. Topics addressed include examining engineering education in countries ranging from India to America, to racial and gender equity in engineering education and incorporating social awareness into the area. Using context as "bridge" this book confronts engineering education head on. Contending engineering ideologies and corresponding views on context are juxtaposed with contending discourses of reform. The uniqueness of the book is that it brings together scholars from the humanities, the social sciences and engineering from Europe - both East and West - with the United States, China, Brazil, India and Australia. (shrink)

We describe a novel Internet-based method for building consensus and clarifying con icts in large stakeholder groups facing complex issues, and we use the method to survey and map the scienti c and organizational perspectives of the arti cial life community during the Seventh International Conference on Arti cial Life (summer 2000). The issues addressed in this survey included arti cial life’s main successes, main failures, main open scienti c questions, and main strategies for the future, as well as the (...) bene ts and pitfalls of creating a professional society for arti cial life. By illuminating the arti cial life community’s collective perspective on these issues, this survey illustrates the value of such methods of harnessing the collective intelligence of large stakeholder groups. (shrink)

What makes a cell? How are cells able to replicate themselves in a stable manner? How did cellular life emerge on our planet? The answer to these fundamental questions lies at the base of biology. Cellular life is the basic unit of living organization and defines the presence of a stable information reservoir connected through the external world by a well-defined boundary. Inside the cell, chains of computations and chemical reactions take place, sustained by self-assembled molecular machines. At the cell (...) membrane, the environment and the cell communicate with each other through proteins that are able to detect small concentration changes and send the appropriate signals. But modern cells are very sophisticated entities and extracting the logic of cell organization from them is a gigantic effort. In order to answer these questions, we need to look at cells in a more basic level: a reduction of complexity is needed. Protocells, roughly defined as the simplest instances of autonomous cell-like structures, have been a matter of exploration for decades. Although most of the original work in this area was largely theoretical, the end of the twentieth century was marked by very active experimental research on minimal cells. One approach has been the top-down strategy, where living organisms (the simplest life forms) are being selectively modified to reduce their genome complexity. Such a minimal genome would be the smallest one able to sustain reproduction and growth under a given set of external constraints (mainly available molecules). The second approach is the bottom-up one, very much in the tradition of research into the origins of life. Under this approach, extremely simple life forms are built from basic chemical components, including lipids and a basic.. (shrink)

We argue that Bohrian complementarity is a framework for making new ontological sense of scientific findings. It provides a conceptual pattern for making sense of the results of an empirical investigation into new realms or fields of natural properties. The idea of “formation length” engenders this mutual attunement of evidence and reality. Physicists want to be able to ascribe ontological features to atomic constituents and atomic processes such as “emission”, “impact”, or “change of energy-state”. These expressions supposedly refer to “local” (...) forms of physical change that in sum constitute the possibility of there being a “global” (for example an atomic) system of possible states. We argue that it is only because we can act it out in the design of experiments that we canmake sense of the link between classical and quantum theoretical systems. We need the notion of formation length in order to express the principle that the atom is a causal unity. This not in the sense of being the ground for a particular kind of causality, but in the sense of unifying the grounds for the variety of causal manifestations that constitutes the atom. (shrink)

In the paper I try, resolutely, to associate the open ended encyclopedic character of Cassirer's philosophy with the core part of this philosophy concerning symbolic formation. In this way I try to supplement and strengthen the anthropology that Cassirer formulated in AN ESSAY ON MAN. Finally I discuss the historical character and value of this anthropology.

In this essay, I will discuss a variety of considerations that Goethe expressed in his writings. I will with few exceptions address these writings in chronological order. I include both literary and scientific-philosophical works. In this way I hope to show that a certain theme is at the heart of Goethe’s thinking, and that Goethe’s later works expresses a sophisticated and “deep” account of this theme. In addition, I will try to explain how one can ascribe this Goethean theme to (...) major philosophers of the twentieth century – Cassirer, Merleau-Ponty, and Wittgenstein. The theme in question concerns the individuality of a human life in a metaphysical sense, characterizing the individual as situated “in between” Nature and Culture. By being both a child of Nature and a child of Culture, the fate of individuals is the transformation of previously given human concerns and practices. There never is a natural child nor a cultural formation securing human individuality. In Goethe’s words: The history of an individual human being is the individual human being. “Die Geschichte der Wissenschaft ist die Wissenschaft selbst, die Geschichte des Individuums, das Individuum”. See Hamacher. Hamacher’s book has been a major source for me! (shrink)

In this article, drawing on the discursive psychology of Rom Harré, we show how mapping the exchange of words among people might disclose a complex reality; not merely that which farmers explicitly talk ‘about’ but the reality implicitly at stake within the communication. More specifically, we show how discourses involving modern farmers reveal an underlying placing in an abstract space, having sub-spaces defined by the life-orientation, sense of self and according self-positioning of modern people. In this way, we construct a (...) road map of a set of ‘individualities’ characterizing the life of modern farmers: an individuality of citizenship, an individuality of geographies and an individuality of experience. Consequently, farmers face the problem that this multiplicity of individuality prevents them from communicating, as we will call it, univocally in the public by contrast to the univocal voices of other established social groups. We will analyse the structure of that problem by viewing diverse relations between the authority and the authenticity of different partners in the conversation on land use. (shrink)

We investigate the relationship of corporate social responsibility (CSR) (often assumed to reflect corporate voluntarism) and government (often assumed to reflect coercion). We distinguish two broad perspectives on the CSR and government relationship: thedichotomous(i.e., government and CSR are / should be independent of one another) and therelated(i.e., government and CSR are / should be interconnected). Using typologies of CSR public policy and of CSR and the law, we present an integrated framework for corporate discretion for engagement with public policy for (...) CSR. We make four related contributions. First, we explain the dichotomous and the related perspectives with reference to their various assumptions and analyses. Second, we demonstrate that public policy for CSR and corporate discretion coexist and interact. Specifically, we show, third, that public policy for CSR can inform and stimulate corporate discretion and, fourth, that corporations have discretion for CSR, particularly as to how corporations engage with such policy. (shrink)

In 2017 we published a paper in this journal proposing a philosophical framework for recognizing ecological communities as natural entities, the Evolutionary Community Concept. That paper attracted a lengthy reply; herein we take the opportunity to clarify critical aspects of the ECC and use a case study to demonstrate how the ECC can be made operational. We maintain the ECC provides a framework useful for establishing objectives associated with ongoing and proposed restoration and conservation efforts.

Ontology and epistemology will never be reconciled, this article argues. There is widespread opinion among scientists and laymen alike that we are standing at the threshold of a fusion and reconciliation of ontology and epistemology. But my thesis is that this will never happen – and my argument can be read as a credo for non-identity. The tensions between being and thinking are here to stay, and this philosophical ‘position’ has a wide range of implications for politics, education, Bildung and (...) thinking. Strongly rooted in Theodor Wiesengrund Adorno’s philosophy, it is claimed that he was right in emphasizing that the non-identical must be honored, defended and emancipated. The vivid dream is that conceptual work opens and ‘dignifies’ the non-identical, while the non-identical ‘longs for’ conceptual assistance so it can come to exist among us. (shrink)

The correspondence view of memory is not a metaphor. However, correspondence is the essential feature of the archaeology metaphor, which harks back to Freud and Neisser. A modern version of this metaphor and some of its implications are briefly described. The archaeology metaphor integrates the idea of stored traces in a nonmechanistic framework.